Widespread Cortical Thickness Changes After Mesial Temporal Resection in Temporal Lobe Epilepsy
Abstract number :
3.241
Submission category :
5. Neuro Imaging / 5A. Structural Imaging
Year :
2022
Submission ID :
2204510
Source :
www.aesnet.org
Presentation date :
12/5/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:25 AM
Authors :
Caitlin Grogan, – Vanderbilt University; Lucas Sainburg, BS – Graduate Student, Biomedical Engineering, Vanderbilt University; Behnaz Akbarian, MS – Graduate Student, Biomedical Engineering, Vanderbilt University; Baxter Rogers, PhD – Radiology and Radiological Sciences – Vanderbilt University Medical Center; Dario Englot, MD, PhD – Neurological Surgery – Vanderbilt University Medical Center; Victoria Morgan, PhD – Radiology and Radiological Sciences – Vanderbilt University Medical Center
Rationale: Temporal lobe epilepsy (TLE) and surgical interventions cause widespread changes in the brain, which may be quantified by cortical thickness measurements. TLE patients are known to experience cortical thinning at a rate greater than normal thinning attributed to aging, and surgical resection of the epileptic focus may slow this progression.1 We aimed to quantify this progression in our own cohort of patients pre and post-surgery. We hypothesized that surgery has varied effects on cortical thickness trajectories with age in TLE patients.
Methods: Eighteen right and 7 left TLE patients who underwent selective amygdalohippocampectomy surgery took part in this study. All patients underwent pre and postsurgical T1 weighted 3D scans (1x1x1 mm3). FreeSurfer software was used to compute cortical thickness in 64 regions from the Desikan-Killiany-Tourville atlas. Age corrected cortical thickness values were calculated for patients by computing a linear correlation between age and thickness for healthy controls (n=56). Using this, raw patient thickness values were converted to standard deviations from age-matched controls. Paired t-tests were run between pre and postsurgical corrected thickness values for both right and left TLE patients. One sample t-tests were run on the corrected thickness in each region to determine if they differed from the age-matched control thicknesses. All results are reported with correction for multiple comparisons (p< 0.0008) and without (p< 0.05).
Neuro Imaging