Abstracts

Rationale: Coriaria Lactone (CL) is an convulsant chemical substance extracted from a Chinese medical herb called Loranthus. CL kindling model has been reported with relatively higher seizure-induction rate and lower mortality. Yet up to date, there haven’t been any report regarding the cognition-related behavior of this model. This research aims to assess the anxiety-related, depression-related and memory-related behavior on CL kindling model. Methods: Ten wistar rats were equally separated into two groups. One group were injected with CL by intraperitoneally every 2 days to establish the seizure model. Control group were administered 0.9% NS. Open field exploration test, light left right arrow dark exploration test, cue and contextual fear conditioning, forced swimming test and water maze tasks were done to analyze anxious, depressive, and memory behavior. Results: CL kindling model show depressive behavior, while no anxiety-related behavior compared with the control. Contextual conditioning were impaired while cue conditioning were obtained in CL kindling model. Water Maze tasks show disturbed spatial memory. Conclusions: Epilepsy frequently comorbid with depression, and might share some common mechanisms. CL kindling model, like other epilepsy models, also comorbid with depressive symptoms, which further support the close relationship between epilepsy and depression. CL kindling model also have the potential as a model for memory dysfunction research in epilepsy.  Funding: This abstract has been supported by Sichuan Province Science and Technology Project (2017HH0103).