Abstracts

L-alpha-glycerylphosphorylcholine enhances hippocampal neurogenesis and cognitive function in pilocarpine seizure-induced neuronal death and cognitive impairment

Abstract number : 1.045
Submission category : 1. Translational Research: 1A. Mechanisms / 1A4. Mechanisms of Therapeutic Interventions
Year : 2016
Submission ID : 194428
Source : www.aesnet.org
Presentation date : 12/3/2016 12:00:00 AM
Published date : Nov 21, 2016, 18:00 PM

Authors :
Hong ki Song, Hallym University Medical Center; Dong jin Shin, Gachon University College of Medicine; Hui chul Choi, Department of Neurology, Hallym University Medical Center; and Sang won Suh, Department of Phsiology, Hallym University

Rationale: .L-alpha-glycerylphosphorylcholine (a-GPC) is a natural choline compound found in the brain. a-GPC is used to enhance memory and cognition for stroke and Alzheimer's patients but currently remains untested in patients suffering from epilepsy. This study aimed to evaluate whether a-GPC treatment after seizure can ameliorate seizure-induced cognitive impairment and neural injury. Methods: Seizure was induced by intraperitoneal (i.p) injection of pilocarpine (25 mg/kg) in adult male rats. a-GPC (250 mg/kg) was injected into the intramuscular (i.m) space three weeks after seizure onset for three weeks once-daily administration. To evaluate if treatment with a-GPC provides protection to hippocampal dependent cognitive abilities following seizure we analyzed subject performance using a standard water maze test protocol and brain NeuN immunohistochemistry to determine hippocampal neuronal survival. All groups were sacrificed at 6 weeks post-seizure. Results: we observed enhanced survival of hippocampal neurons and improved cognitive function in animals receiving a-GPC injection after pilocarpine-induced seizure. Conclusions: This result suggests that increase of hippocampal acetylcholine by a-GPC is associated with increase of hippocampal neurogenesis and improvement of cognitive function. Therefore, a-GPC administration may serve as a beneficial treatment for improvement of cognitive function in epilepsy patients. Funding: None
Translational Research