Language Dominance in Children as Determined by Magnetic Source Imaging and the Intracarotid Amobarbital Procedure: A Comparison.
Abstract number :
B.10
Submission category :
Year :
2000
Submission ID :
3332
Source :
www.aesnet.org
Presentation date :
12/2/2000 12:00:00 AM
Published date :
Dec 1, 2000, 06:00 AM
Authors :
James W Wheless, Joshua I Breier, P G Simos, Jules E Constantinou, James E Baumgartner, Vijay Venkataraman, Andrew C Papanicolaou, Univ of Texas - Houston, Houston, TX.
RATIONALE: To evaluate the validity of data derived from Magnetic Source Imaging (MSI) regarding hemispheric dominance for language in children and adolescents with intractable seizure disorder by comparison with results of the intracarotid amobarbital procedure (IAP). METHODS: Functional imaging of the receptive language cortex using a whole head neuromagnetometer was performed in 19 consectutive epilepsy patients, ages 8 to 18 years, who also underwent the IAP. During MSI recordings, patients engaged in a continuous recognition memory task for words in visual and auditory modalities. This task has previously been shown to be valid for the purpose of lateralization and localization of language cortex in adult epilepsy patients who undergo the IAP and intraoperative language mapping allowing the confirmation of MSI findings. RESULTS: Language laterality indices formed for IAP and MSI procedures where highly correlated (r= .87). In addition, clinical judgements regarding cerebral dominance for language made using the two methods by independent raters where in excellent agreement. CONCLUSIONS: MSI is a promising method for determination of cerebral dominance for language in children as well as adults.