Recurrent Clustering and Suppression Periods of Seizures Strongly Suggest Focal Cortical Dysplasia in Drug-Resistant Epilepsies
Abstract number :
3.206
Submission category :
4. Clinical Epilepsy / 4B. Clinical Diagnosis
Year :
2019
Submission ID :
2422104
Source :
www.aesnet.org
Presentation date :
12/9/2019 1:55:12 PM
Published date :
Nov 25, 2019, 12:14 PM
Authors :
Kenji Sugai, National Center of Neurology and Psychia; Yoshihiko Saito, National Center of Neurology and Psychia; Mahito Atobe, National Center of Neurology and Psychia; Takashi Saito, National Center of Neurology and Psychia; Eiji Nakagawa, National Cent
Rationale: Focal cortical dysplasia (FCD) is a good candidate for epilepsy surgery and can achieve good seizure outcome by surgery, however, surgical evaluation and surgery are hesitated and delayed in MRI-negative cases. We encountered MRI-positive and MRI-negative drug-resistant epilepsy (DRE) cases with recurrent clustering and suppression of seizures (RCSSz), which were pathologically proven to have FCD after surgery. We tried to clarify characteristic seizure pattern in DRE patients with FCD. Methods: RCSSz was defined as >2 clustering periods of seizures (Sz) (>10 Sz/day lasting for >1 week) and >2 suppression periods of Sz (no Sz for >1 week). The suppression period varied weeks to years. Among 419 cases of DRE <
Clinical Epilepsy