Evidence-based guidance for the diagnosis and management of infantile epilepsy.
These infantile epilepsy guidelines provide evidence-based recommendations to support clinicians in the early identification, diagnosis, and management of epilepsy in infants. Developed by experts in neurology and neonatal care, the guidelines synthesize current research and clinical best practices to improve patient outcomes during a critical period of neurological development. Resources on this page include the full guideline publication, clinical algorithms, and additional tools designed to support real-world clinical decision-making.
The management of infantile epilepsy continues to evolve rapidly, driven by advances in diagnostics, genetics, and targeted therapies. This webinar will provide a focused review of newly published infantile epilepsy management guidelines, with emphasis on medication, surgical, and dietary treatment strategies. Expert faculty will highlight key updates, including the evidence supporting specific therapies and guidance on when to refer patients to a specialized epilepsy center. Through clinically relevant discussion, attendees will learn how to incorporate these guidelines into real-world decision-making, optimize early intervention, and improve neurodevelopmental outcomes. Designed for pediatric neurologists, dietitians, pediatricians, and neurosurgeons, this session will also address ongoing controversies, implementation challenges, and future directions in infantile epilepsy care.
Panelists: Elissa Yozawitz, MD and Daniel Freedman, DO
In this Clinical Corner episode, experts discuss the new American Epilepsy Society (AES) guideline for infantile epilepsy—an important milestone for a field that has long lacked standardized guidance. “Tiny Brains, Big Decisions: Infantile Epilepsy Treatment Today” features Elissa Yozawitz, MD; John Stern, MD, MA; and Daniel Freedman, DO, who break down key recommendations from the Epilepsy Currents (Spring 2026) publication.
Clinical Algorithms
Visual decision-support tools derived from the Infantile Epilepsy Guidelines to assist in the diagnosis and management of infantile epilepsy.
A high-level clinical pathway outlining diagnostic evaluation, treatment progression, and escalation to drug-resistant epilepsy care.
Guidance on first- and second-line antiseizure medications by epilepsy type, with escalation strategies for drug-resistant epilepsy.
Decision-making framework for referral, surgical candidacy, and dietary therapy in infants with persistent seizures.
Read the complete Infantile Epilepsy Guidelines publication.
Download a PDF copy of the guidelines for reference or sharing.
A quick reference summary for clinical use.