Association between calcified neurocysticercosis and drug-resistant epilepsy in a referral center in Mexico
Abstract number :
1.394
Submission category :
Camelice Poster
Year :
2021
Submission ID :
1886445
Source :
www.aesnet.org
Presentation date :
12/4/2021 12:00:00 PM
Published date :
Nov 22, 2021, 06:56 AM
Authors :
Juan Camilo Cotuá Urzola, MD, - neurosabanas; jose Lee Chang Segura, MD - National Institute of Neurology and Neurosurgery MVS; Mario Alonso Vanegas, MD - National Institute of Neurology and Neurosurgery MVS; Agnès Fleury, MD - National Institute of Neurology and Neurosurgery MVS; mario Alberto Sebastian-Diaz, MD, PHD - Anahuac North University; jimena Baez Armenta, MD - National Institute of Neurology and Neurosurgery MVS; Karen Edith Guzman sanchez, MD - National Institute of Neurology and Neurosurgery MVS; Andrea Santos-Peyret, MD - National Institute of Neurology and Neurosurgery MVS; Iris Enriqueta Martinez Juarez, MD, MSG - National Institute of Neurology and Neurosurgery MVS
Rationale: To determine the relationship between the number and location of calcified neurocysticercosis (NCC) lesions and the presence of drug-resistant epilepsy (DRE) in patients treated at the NINN “MVS” in Mexico, city. The association of neurocysticercosis (NCC) with drug-resistant epilepsy (DRE) is rare (1). The prevalence of DRE in the NINN “MVS” is of 56%, including in that sample 2.4% of patients with NCC who presented DRE (2).
Methods: A cross-sectional, analytical, retrospective study was performed, patients with calcified NCC attended at NINN “MVS” Epilepsy Clinic from 2013 to 2019 were included. The SPSS v 18.0 program was used for analysis.
Results: Forty-one patients were included. Mean age was 48 ± 12.1 years, 24 (58.5%) were female, the mean age at seizure onset was 24.5 ± 16.2 years. The mean number of NCC lesions per patient was 3.44 ± 6. Thirteen patients (31.7%) were seizure-free. 22 patients (53.7%) had a single calcified lesion. Patients with fewer calcified NCC lesions were associated with better seizure control p=0.05. NCC were in the temporal lobe in 25 patients (61%) and 16 (39%) had extratemporal lesions, with no differences regarding seizure freedom (p=0.73), however patients with NCC in the temporal region were taking more antiseizure drugs (ASD) 2.04 vs 1.5 in patients with extratemporal NCC (p=0.05).
Conclusions: The presence of more NCC lesions was associated with DRE. The location of the NCC lesions in the temporal lobe did not increase the drug resistance, however, it was associated with a greater use of ASD.
Funding: Please list any funding that was received in support of this abstract.: no.
Camelice Poster