Abstracts

Rationale: To find the risk factors affecting the development of drug-resistant epilepsy (DRE) among post-traumatic epilepsy (PTE) patients, and to provide a reference point for PTE disease modifying treatment.

Methods: We conducted a retrospective clinical analysis in patients with PTE who visited the outpatient Department of Epilepsy, Beijing Tiantan Hospital from January 2013 to December 2018. All participants were followed-up for at least 2 years, the usage of antiepileptics drugs (AEDS) and drug response were concerned, and PTE patients who developed DRE were identified. Parameters of interest included gender, age at TBI, family history of epilepsy, severity of TBI, single or multiple injuries, post-TBI treatments, residual disability, acute seizures, the latency of PTE, seizure type of PTE, status epilepticus, electroencephalogram (EEG) results, and neuroimaging results. SPSS 23.0 software was used for univariate comparisons, as were multivariable analysis to identify the independent risk factor for DRE.

Results: Complete clinical information was available for 2856 PTE patients, of which 78.47% were males, and the mean age at TBI was 21.4 ± 15.1 years. The rate of DRE was 19.99% (DRE, n = 571; no-DRE, n = 2258). The results of the univariate analyses showed that gender (P = 0.052), age at TBI (P < 0.001), single or multiple injuries (P < 0.001), residual disability (P < 0.001), seizure type of PTE (P < 0.001), status epilepticus (P < 0.001), electroencephalogram (EEG) results (P < 0.010), and neuroimaging results (P < 0.087) was associated with the development of DER. Multivariable analysis showed that ≥ 18 years old (OR = 0.699), multiple injuries (OR = 1.274), residual disability (OR = 1.681), focal onset epilepsy (OR = 1.170), status epilepticus (OR = 1.936) affect the development of DRE independently.

Conclusions: PTE patients who had multiple injuries, residual disability, focal onset epilepsy, status epilepticus were more likely to develop DRE, and it is necessary to conduct a comprehensive evaluation and seek treatment alternatives to AEDs in the early stage of PTE.

Funding: Please list any funding that was received in support of this abstract.: National Key R&D Program of China 2017YFC1307500, Capital Healthy Development Research Funding 2016-1-2011 & 2020-1-2013.