Abstracts

Rationale: The Modified Atkins Diet is gaining prominence as a possible therapy for drug-resistant epilepsy, particularly in the paediatric and adolescent population. However, very few studies have been conducted to assess its efficacy in adults

Methods: We conducted a systematic review of existing literature to assess for RCTs and prospective observational studies assessing the efficacy of Modified Atkins Diet(MAD) in adults. The inclusion criteria was as follows: All Randomized Control Trials and Observational Studies with free, full-text articles available in English, published in the 21^st century (January 2000 through May 2023). The exclusion criteria was defined as Case studies, Case reports, studies without data on the adult population and all papers where the free, full-text version could not be procured and articles involving the pediatric population. In view of the limited literature available the primary outcome was simply defined as greater than 50% seizure reduction at the end of the study duration.

Results: Our literature search using a Boolean strategy revealed three randomized control trials assessing more than 50% seizure reduction at the end of two months, three months, and six months respectively, and four prospective studies that fit the criteria, where we assessed the primary outcome of more than 50% seizure reduction at the end of one month and at the end of three months.

A total of 32.5% in MAD group in contrast to 3% individuals in control group showed more than 50% seizure reduction with odds ratio [95% CI] 12.62 [4.05-39.29], p value < 0.0001, hence was statistically significant). Four participants who underwent intervention with MAD achieved complete seizure-free status in contrast to zero participants in the control group, odds ratio [ 95% CI] 16.20 [0.82-318.82], p value= p= 0.07.