Endovascular Electroencephalography (eEEG) Can Detect the Laterality of Epileptogenic Foci as Accurately as Subdural Electrodes
Abstract number :
1.231
Submission category :
2. Translational Research / 2D. Models
Year :
2024
Submission ID :
795
Source :
www.aesnet.org
Presentation date :
12/7/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Ayataka Fujimoto, MD.PhD. – Seirei Hamamatsu General Hospital
Yuji Matsumaru, MD, PhD – University of Tsukuba
Yosuke Masuda, MD, PhD – University of Tsukuba
Keishiro Sato, MD. – Seirei Hamamatsu General Hospital
Keisuke Hatano, MD/PhD – Wayne State University
Shingo Numoto, MD. – Seirei Hamamatsu General Hospital
Aiki Marushima, MD, PhD – University of Tsukuba
Hisayuki Hosoo, MD, PhD – University of Tsukuba
Kota Araki, MD – University of Tsukuba Hospital
Tohru Okanishi, MD, PhD – Tottori University
Eiichi Ishikawa, MD, PhD – University of Tsukuba
Rationale: Endovascular electroencephalogram (eEEG) has been shown to detect discharges in pigs with a 97% sensitivity, undetectable by scalp EEG but captured by subdural electrodes (SD) (Brain Sci. 2022 Feb 24;12(3):309). The next challenge is to determine whether eEEG can identify epileptic foci. This study hypothesizes that eEEG can ascertain the laterality of epileptic foci and evaluates this in pigs with lateralized foci.
Methods: eEEG electrodes were placed in the transverse sinuses of three pigs (F00001-00003) with SDs on both hemispheres. Epileptogenicity was induced using penicillin in the left brain of pigs F00001 and F00003, and in the right brain of F00002. Discharges were recorded with eEEG and compared to SD detections. Twelve neurologists independently reviewed the eEEG results to determine laterality.
Results: eEEG evaluations were in agreement with SD (p ≤ 0.001). Sensitivity and PPV were 0.93 and 0.96 for F00001, 0.99 and 1.00 for F00002, and 0.98 and 0.99 for F00003. One neurologist misjudged all laterality determinations, but the other evaluations were accurate.
Conclusions: eEEG reliably determined laterality with high sensitivity and PPV, comparable to SD. Several neurologists, not involved in the study, objectively determined laterality. This study, published in Heliyon (2024 Feb 1;10(3)
), adhered to NIH guidelines for animal care and was approved by Nihon Bioresearch Inc.'s committee (study no. 420219). Efforts were made to minimize suffering for the three Gottingen miniature pigs used.
Funding: This research was supported by the Japan Agency for Medical Research and Development (AMED) under grant number
JP23he0122011.
Translational Research