Authors :
Presenting Author: Ramiro Ruiz-Garcia, MD – National Institute of Neurology and Neurosurgery
Elma Paredes-Aragon, MD – National Institute of Neurology and Neurosurgery
Gabriela Moscol Ato, MD – London Health Sciences Centre
Christine Le, MD – London Health Sciences Centre
Rosario Teran-Mejia, MD – McGovern Medical School, The University of Texas Health Science Center at Houston
Norah Alkhaldi, MD – Imam Abdulrahman Bin Faisal University
seyed Mirsattari, PHD – Mayo Clinic Florida
Irene Gomez Oropeza, MD – National Institute of Neurology and Neurosurgery
Rationale:
Rationale: Postictal psychiatric manifestations remain poorly characterized in People with Epilepsy (PWE). One potential explanation is the fact that PWE rarely looks for help due these symptoms, complicating the comprehension of its clinical implications. We aimed to describe the postictal psychiatric features and potential associations in a sample of PWE
admitted to an Epilepsy Monitoring Unit (EMU).
Methods:
Methods: A case-control study was designed. Cases were defined as PWE presenting a clinical and EEG confirmed seizure during hospitalization, and Controls as PWE without seizures during admission. Subjects with ‘secondary etiologies’ were excluded. Neuropsychiatric Inventory (NPI) and Neurological Disorders Depression inventory in Epilepsy (NDDI-E) were applied at admission (T1) and 72 hours after a seizure for cases or 72 hours after admission in controls (T2). This protocol was accepted by the research ethics committee of UWO.
Results:
Results: A total sample of 65 participants (Cases: 45, Controls: 20) were included. Groups did not statistically differ in terms of demographic data or clinical features of epilepsy with the exception of age (Table 1). Of 45 cases, 42 (93.3%) exhibited diverse postictal psychiatric manifestations. No differences were found at T1 total and T2 total or individual items in NDDI-E scores. However, the prevalence of depression (NDDI-E score ≥11) was high in both groups at both times (~80%). At T1, controls presented increased severity and frequency of hallucinations (0.65 vs 0.12, t=14.2, p< 0.001