FDG-Positron Emission Tomography and Surgical Outcome of Temporal Lobe Epilepsy: Severity and Extent of Hypometabolism Quantified by Probabilistic Atlas of Brain.
Abstract number :
1.217
Submission category :
Year :
2001
Submission ID :
184
Source :
www.aesnet.org
Presentation date :
12/1/2001 12:00:00 AM
Published date :
Dec 1, 2001, 06:00 AM
Authors :
J-B. Oh, Neurology, Seoul National University Hospital, Seoul, Republic of Korea; S.K. Lee, Neurology, Seoul National University Hospital, Seoul, Republic of Korea; J.S. Yeo, Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea;
RATIONALE: To evaluate the relation between hypometabolism on FDG-PET and surgical outcome of a large and homogeneous series of mesial temporal lobe epilepsy (mTLE) with a probabilistic atlas of human brain (Statistical Probabilistic Anatomical Maps: SPAM).
METHODS: Eighty-two surgically proven intractable mTLE patients and 22 age-matched controls were spatially normalized to the average brain MRI template of international consortium of brain mapping (ICBM). The diagnosis of mTLE was confirmed by the presence of hippocampal sclerosis on MRI and video-EEG monitoring. Counts from normalized PET images were multiplied with the probability of 12 VOIs from SPAM images in both temporal lobes. Asymmetric indices (AI) reflecting severity of hypometabolism were calculated on each pair of VOIs. Extent of hypometabolism was determined by number of pixels (p[lt]0.05) with decreased metabolism. We evaluated the relationship of AI of each VOI and extent of hypometabolism with surgical outcome.
RESULTS: Of the 82 patients studied, 74 (90.2 %) were seizure free and 8 (9.8%) had postoperative seizures at the 2-year follow-up evaluation. No significant association of the severity of hypometabolism in temporal lobe and surgical outcome was identified (p[gt]0.05). Number of pixels of decreased hypometabolism was not significantly different between good and poor outcome groups (p[gt]0.05)
CONCLUSIONS: These findings suggest that neither severity nor extent of hypometabolism is related with surgical outcome in a homogeneous series of mTLE although it helps to identify seizure foci.