Frequency of seizures in pediatric patients with neuroinflammatory disease with and without myelin oligodendrocyte glycoprotein antibodies (MOG-Ab)
Abstract number :
503
Submission category :
4. Clinical Epilepsy / 4A. Classification and Syndromes
Year :
2020
Submission ID :
2422845
Source :
www.aesnet.org
Presentation date :
12/6/2020 5:16:48 PM
Published date :
Nov 21, 2020, 02:24 AM
Authors :
Kathryn Elkins, Emory University; Azalea Lee - Emory University; Grace Gombolay - Emory University;;
Rationale:
Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are increasingly found in patients with inflammatory demyelinating diseases (IDD).1 MOG-Ab positive patients were more likely to have seizures as compared to those with neuromyelitis optica spectrum disorders (NMOSD);2,3 however, limited data exists in whether MOG-Ab confers increased risk for seizures in pediatric IDD. This study examines seizure frequency in pediatric patients with neuroinflammatory disease with and without MOG-Ab.
Method:
Retrospective chart review was performed at a single center (Children’s Healthcare of Atlanta) on pediatric patients diagnosed with IDD or MOG-ab. Characteristics including MOG-Ab status, type of IDD, symptoms (including seizures), and CSF studies were recorded. Statistical analysis included Student’s t-test and multivariate ANOVA using Stata.
Results:
Twenty-one MOG-Ab positive patients and 39 MOG-Ab negative patients identified. In MOG-Ab patients, disease types included acute disseminated encephalomyelitis (ADEM) (7), optic neuritis (6), multiple sclerosis (MS) (3), NMOSD (2), aseptic meningitis (2), and acute stroke-like presentation (1). In the MOG-Ab negative patients, disease types included MS (28), NMOSD (6) and ADEM (5). Regarding seizures, 7/21 MOG-Ab (33%) positive had seizures compared to 2/39 (5.1%) MOG-Ab negative patients (p=0.0028). Other characteristics that were different between the two groups included age of presentation (p=0.0002), relapse of disease (p=0.0007), and type of diseases within each group (p = 0.0136) (Table 1).
Conclusion:
Patients with MOG-Ab are more likely to have seizures than those without MOG-Ab. MOG-Ab positive patients are also more likely to be younger and are less likely to have relapses. Further investigation is needed to determine why MOG-abs are associated with increased risk for seizures.
References
•Reindl M, Waters P. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol. 2019;15(2):89-102.
•Hamid SHM, Whittam D, Saviour M, et al. Seizures and Encephalitis in Myelin Oligodendrocyte Glycoprotein IgG Disease vs Aquaporin 4 IgG Disease. JAMA Neurol. 2018;75(1):65-71.
•Yao Y, Xu Y, Ren H, et al. Acute epileptic seizures in myelin oligodendrocyte glycoprotein encephalomyelitis and neuromyelitis optica spectrum disorder: A comparative cohort study. Mult Scler Relat Disord. 2019;27:281-288.
Funding:
:None
Clinical Epilepsy