Abstracts

Heart Rate Elevation in Left Temporal Lobe Epilepsy with Neocortical Lesions

Abstract number : 2.115
Submission category : 3. Neurophysiology / 3A. Video EEG Epilepsy-Monitoring
Year : 2024
Submission ID : 524
Source : www.aesnet.org
Presentation date : 12/8/2024 12:00:00 AM
Published date :

Authors :
Presenting Author: Ayu Takano, BSc – Tohoku University Graduate School of Medicine

Kazushi Ukishiro, MD, PhD – Tohoku University Graduate School of Medicine
Temma Soga, MD – Tohoku University Graduate School of Medicine
Kazutaka Jin, MD, PhD – Tohoku University Graduate School of Medicine
Izumi Itabashi, MSc – Tohoku University hospital
Shin-ichiro Osawa, MD, PhD – Tohoku University Graduate School of Medicine
Masaki Iwasaki, MD, PhD – National Center of Neurology and Psychiatry
Hidenori Endo, MD, PhD – Tohoku University
Nobukazu Nakasato, MD, PhD – Tohoku University Graduate School of Medicine

Rationale: Rationale: It is well known that the heart rate (HR) increases during seizures in temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS). In the present study, we investigated whether HR would increase during neocortical seizures in the left TLE.

Methods: Methods: We reviewed patients with drug-resistant epilepsy with left TLE with neocortical lesions who underwent lesionectomy without (group A) or with (group B) amygdalo-hippocampectomy (AH) and left TLE with HS who underwent selective AH (group C) between 2010 and 2022. We included patients with post-surgical seizure freedom only to categorize whether epileptogenicity underlies in mesial alone, neocortical alone or both, i.e., dual pathology. All EEG data we reviewed were recorded preoperatively. HR elevation rate was measured from EEG onset to maximumHR during seizures, with comparisons made between groups on a seizure and patient basis.


Results: Results: Group A (n=7) had 22 seizures, Group B (n=6) had 44 seizures, and Group C had 11 seizures. In a seizure-based analysis, HR elevation rate was significantly lower in Group A than C (p < 0.001). No significant differences were found between Group A and B, as well as between Group B and C. Similarly, in a patient-based analysis of averaged HR increase in the captured seizures, HR elevation was significantly (p < 0.001) lower in Group A than C, but not in the other comparisons.
Neurophysiology