HIPPOCAMPAL TEXTURE ANALYSIS IN PATIENTS WITH MESIAL TEMPORAL SCLEROSIS
Abstract number :
3.158
Submission category :
Year :
2002
Submission ID :
1843
Source :
www.aesnet.org
Presentation date :
12/7/2002 12:00:00 AM
Published date :
Dec 1, 2002, 06:00 AM
Authors :
Eliane Kobayashi, Li M. Li, Eduardo Tinois, Fernando Cendes. Department of Neurology, UNICAMP, Campinas, SP, Brazil; Department of Neurology, UNICAMP, Campinas, SP, Brazil; Center for Biomedic Engeneering, UNICAMP, Campinas, SP, Brazil; Department of Neur
RATIONALE: Mesial temporal lobe epilepsy (MTLE) is frequently associated with refractory seizures and pathological features of mesial temporal sclerosis (MTS). New quantitative MRI techniques can improve the detection and quantification of hippocampal abnormalities. Texture (Txt) analysis has been successfully used in cerebral pathologies and can be used for evaluation of mesial temporal lobe structures. The objective of this study is to evaluate Txt analysis in patients with pathologically proven MTS and refractory MTLE.
METHODS: We selected 20 consecutive patients with refractory MTLE who underwent surgical treatment and had pathological findings consistent with MTS. We performed Txt analysis in 3mm coronal T1-IR MRIs, using the software MAZDA[reg], focusing on operated hippocampal head. Txt parameters that were highly influenced by the size of the region of interest (ROI) were excluded, as well those related only to brightness and contrast. Data was compared to a group of 20 healthy adult volunteers. For statistical analyses, we determined most significant parameters, through ANOVA and MANOVA.
RESULTS: We studied 20 operated patients (12 women and 8 men) with MTS (12 right and 8 left). MAZDA[reg] generates data on 250 parameters. We selected 44 parameters that showed the highest mean difference between patients and controls. The MANOVA showed that parameters that best differentiated normal from abnormal hippocampus in operated patients were: histogram and absolute gradient (p from 0.009 to 0.00003); both were consistently abnormally low in the operated hippocampi, as compared to the control group.
CONCLUSIONS: Txt analyses is promissing in the assessment of hippocampal abnormalities in patients with MTS. These abnormal findings show a straight correlation with the pathological neuronal loss that occurs in MTS. The abnormal Txt analyses in these resected hippocampi indicate a structural simplification of the hippocampal head, which correlates with the MRI observation of a flattened hippocampus, with hypo intense and abnormal internal structure.
[Supported by: FAPESP, S[atilde]o Paulo, Brazil]