Incidence of Post-Stroke Seizures at a Tertiary Center.
Abstract number :
2.326
Submission category :
16. Epidemiology
Year :
2016
Submission ID :
190095
Source :
www.aesnet.org
Presentation date :
12/4/2016 12:00:00 AM
Published date :
Nov 21, 2016, 18:00 PM
Authors :
David T. Chuang, New York Presbyterian- Weill Cornell Medical Center; Blagovest Nikolav, Weill Cornell Medicine-New York Presbyterian Hospital; Hooman Kamel, New York Presbyterian- Weill Cornell Medical Center; and Douglas Labar, Weill Medical College of
Rationale: Stroke is the top cause of acute symptomatic seizures in adults. The reported incidence of post-stroke seizures varies widely and ranges from 2 to 20%. Occurrence of seizure post-stroke has been linked to poorer long term outcome. We set out to ascertain incidence of early (within 1 week of stroke) and late (after 1 week of stroke) seizures at our institution in a well-defined inclusive stroke population, and to identify risk factors for post-stroke seizures. Methods: All patients who were evaluated to receive tissue plasminogen activator for stroke at New York Presbyterian/Weill Cornell between 2012 and 2013 ("stroke code" patients) were entered into our stroke database. To identify patients who then developed post-stroke seizures, records were individually reviewed. Patients were excluded from the current analysis if they had a history of seizures prior to stroke, absence of acute stroke on neuroimaging, or had missing records. Results: 204 patients from database were reviewed. 34 met the exclusion criteria leaving a total of 170 patients in the dataset. The median age was 80 years old and 58.2% were female. Only four patients had early seizure (2.3%). Out of the 170 patients, 133 had post-hospitalization follow up, with a median follow up time of 858 days. Of these 133 patients, 3 had late seizures (2.2%). All patients who had a post-stroke seizure (7/7) had cortical involvement on neuroimaging; among the other 163, cortical involvement was seen in 107/163. There was no association of seizures with other risk factors, including gender, hypertension, hyperlipidemia, and intracranial hemorrhage. Conclusions: Our data is in line with the lower end of reported incidence rate for post-stroke seizure. There are data in the literature suggesting lower incidence rate in older patients and patients treated for stroke in more recent times (after 2000). Our low incidence rate may be a combination of these two factors. Further research on our population will be needed to identify seizure risk factors, since our number of cases with seizures was low. Funding: No funding was received in support of this abstract.
Epidemiology