Late Onset Epileptic Spasms : Clinical and Electrographic Characteristics
Abstract number :
2.088
Submission category :
4. Clinical Epilepsy / 4A. Classification and Syndromes
Year :
2022
Submission ID :
2204328
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:24 AM
Authors :
Eroshini Swarnalingam, MBBS, FRCPC. CSCN (EEG) – Alberta Chidren's Hospital; Juan Pablo Appendino, MD, FRCPC – Alberta Children's Hospital; Alice HO, MD, FRCPC – Alberta Children's Hospital; Morris Scantlebury, MD, FRCPC – Alberta Children's Hospital; Kirsten Sjonnesen, MD – Alberta Children's Hospital; Julia Jacobs, MD, FRCPC – Alberta Children's hospital
Rationale: Since its first description in 1841 by William West, infantile spasms were considered an age specific epileptic phenomenon occurring in infants and in young children. Historically, this term has been used interchangeably to describe both a specific seizure type as well as an infantile epilepsy syndrome and was often used synonymously with West syndrome, generating confusion and debate. Usual spasm onset peaks around the age of 3-12 months and typically presents prior to 36 months. But late onset epileptic spasms (LOES) occurring outside of this typical window of 3-12 months are not uncommon. Existing knowledge on LOES in terms of clinical, electrophysiological and prognostic hallmarks is sparse. Through this study we attempted to systematically evaluate the emergence of LOES and hypsarrhythmia (HA) and investigate their clinical and electrophysiological characteristics in comparison with the earlier onset cohort.
Methods: The Pediatric Epilepsy Database of Alberta Children’s Hospital was systematically interrogated for reports created between 1/1/2016 to 9/10/2021 for epileptic spasms. Age parameters were set at 1-18 years. Records with clear documentation of clinical or electrographic spasms with an onset post 12 months of age were included. At least one EEG capturing sleep was mandatory. Cases with deficient documentation or inaccessible EEGs were excluded. Eligible cases were divided into 2 categories based on presence or absence of HA. An unpaired t test or Pearson’s chi squared test was used for statistical analysis. A p value < 0.05 was considered significant.
Clinical Epilepsy