Plasticity of Language Areas of the Brain in Adult Patients with Medically Refractory Temporal Lobe Epilepsy Following Temporal Lobectomy
Abstract number :
1.176
Submission category :
Human Imaging-All Ages
Year :
2006
Submission ID :
6310
Source :
www.aesnet.org
Presentation date :
12/1/2006 12:00:00 AM
Published date :
Nov 30, 2006, 06:00 AM
Authors :
Lisa Jog, Seyed M. Mirsattari, Donna Bandur, Frank Bihari, Donald H. Lee, David Steven, and Andrew G. Parrent
Few detailed studies of language outcomes following temporal lobectomy (TLY) for patients with medically intractable temporal lobe epilepsy (TLE) have been reported. It remains unknown if there are alterations in the anatomical areas recruited for language., Functional magnetic resonance imaging (fMRI) was used to investigate brain plasticity for language following TLY in eight patients with medically refractory TLE. Three patients underwent left TLY (mean age 46.3 [plusmn] 11.6 years) and five underwent right TLY (mean age 29.2 [plusmn] 7.2 years). Patients silently generated verbs in response to a series of visually presented nouns. Data were analyzed based on region of interest (ROI) activations for inferior frontal gyrus (IFG), midfrontal gyrus (MFG), and Wernicke area (WA). Hemispheric dominance for language was determined using asymmetry indices (AI); AI [gt]0.20 classified as left dominant; AI [lt]0.20 as atypical., Patients that underwent LTLY had increased activation in the RMFG following surgery, and decreased activation in all other areas. The RTLY patients increased activation in all ROIs post-operatively. AI increased in LTLY patients for WA and IFG, but decreased for MFG., Brain plasticity in TLY patients occurs both in frontal regions adjacent to area of resection and in the contralateral hemisphere., (Supported by Lawson Research Institute.)
Neuroimaging