Prenatal Exposure to Antiseizure Medication and Birth Weight Outcomes
Abstract number :
2.157
Submission category :
4. Clinical Epilepsy / 4E. Women's Issues
Year :
2022
Submission ID :
2204273
Source :
www.aesnet.org
Presentation date :
12/4/2022 12:00:00 PM
Published date :
Nov 22, 2022, 05:24 AM
Authors :
Jakob Christensen, MD, PhD, DrMedSci – Aarhus University Hospital; Silje Alvestad, PhD – 6. Department of Clinical Medicine, University of Bergen, Bergen, Norway; Marte-Helene Bjørk, PhD – 6. Department of Clinical Medicine, University of Bergen, Bergen, Norway; Julie Dreier, PhD – 6. Department of Clinical Medicine, University of Bergen, Bergen, Norway; Nils Gilhus, PhD – 6. Department of Clinical Medicine, University of Bergen, Bergen, Norway; Mika Gissler, PhD – 5. Information Services Department, Finnish Institute for Health and Welfare, Helsinki, Finland; Jannicke Igland, PhD – 9. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Yuelian Sun, PhD – 1. Department of Neurology, Aarhus University Hospital, Aarhus, Denmark; Torbjörn Tomson, PhD – 12. Region Stockholm, Academic Primary Health Care Centre, Stockholm, Sweden; Karolinska Institute, Department of Molecular Medicine and Surgery, Stockholm, Sweden; Maarit Leinonen, PhD – 5. Information Services Department, Finnish Institute for Health and Welfare, Helsinki, Finland; Helga Zoega, PhD – 3. Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
This abstract has been invited to present during the Clinical Research platform session
Rationale: This study assesses the association between prenatal exposure to antiseizure medication (ASM) and birth weight outcomes.
Methods: The study combined information from population-based registers of children born in Denmark, Finland, Iceland, Norway, and Sweden between 1996 and 2017 (the SCAN-AED project). We used linear regression to study the association between prenatal monotherapy exposure to ASMs and birth weight in gram (g), and logistic regression to estimate adjusted odds ratios (aOR) for the association with low birth weight ( < 2,500 g) and small for gestational age. We defined small for gestational age as children with a z-score for birth weight according to sex, country, and gestational week at birth < 10% percentile. Estimates were adjusted for potential confounding factors, including maternal age, smoking, substance abuse, cohabitation, income, education, parity, maternal psychiatric disorders and epilepsy, and for maternal use of psychotropic medication. Analyses of birth weight and low birth weight ( < 2,500 g) were also adjusted for gestational age.
Clinical Epilepsy