Abstracts

Rationale: It is well known that generalized status epilepticus (GSE) is a neurological emergency that warrants aggressive and sometimes invasive treatment. However, for partial status epilepticus (PSE), it is not clear how aggressive treatment should be. That is one reason why the duration of PSE tends to be longer than that of GSE. There is evidence that prolonged PSE results in neuronal injury; however the correlation between the duration of PSE and overall prognosis has not been established. Unlike GSE, clinical symptoms are frequently insufficient to monitor PSE. Continuous bedside EEG monitoring is necessary for consistent evaluation of PSE. Methods: Retrospective chart review was performed from January 2008 to January 2012 of all patients who underwent bedside EEG monitoring in our hospital. Prognosis, at the time of discharge, was classified by utilizing Glasgow-Pittsburgh cerebral performance categories (CPC), dividing performance into five categories (1: conscious and alert with a normal function or slight disabilities, 2: conscious and alert with the moderate disabilities, 3: conscious with the severe disabilities, 4: comatose or persistent vegetative state, 5: brain death or death from other causes). All parameters of status epilepticus were obtained through EEG findings and medical records. Results: During this investigation period, 710 bedside EEG monitoring studies were performed. We identified 98 patients with electrographic seizures, and 60 patients were diagnosed as status epilepticus. 52 patients had PSE. Mean age was 60.2. Mean duration of EEG monitoring was 14 hours 27 minutes. Mean CPC score was 2.57. Mean duration of status epilepticus was 56 hours 55 minutes. 8 patients had GSE. Mean age was 59.4. Mean duration of EEG monitoring was 250 hours 35 minutes. Mean CPC score was 4.4. Mean duration of status epilepticus was 41 hours 31 minutes. The prognosis of PSE was found to be better than that of GSE (p=0.0007), but the duration of PSE did not show a statistically significant correlation with prognosis (correlation coefficient -0.12, p=0.35). Conclusions: PSE has better prognosis than GSE. Duration of PSE alone is not correlated with prognosis.