Authors :
Presenting Author: Yun-Jin Lee, MD – Pusan National University Children's Hospital
Juhyun Kong, MD – Pusan National University Children's Hospital; Sooyoung Lyu, MD – Pusan National University Children's Hospital; Sang Ook Nam, MD – Pusan National University Children's Hospital
Rationale:
Myelin oligodendrocyte glycoprotein antibody (MOG−Ab) associated demyelination represents a subgroup of autoimmune demyelination that is separate from multiple sclerosis and aquaporin 4 IgG-positive neuromyelitis optica (NMO) and can have a relapsing course. To investigate the differences in immunopathogenesis based on cytokine/chemokine profile in children of MOG−positive (POS) and −negative (NEG) groups.
Methods:
We measured 24 cytokines/chemokines using multiplex immunoassay in cerebrospinal fluid (CSF) of children with serum MOG−POS [total n=20; acute disseminated encephalomyelitis (ADEM) combined with other demyelinating disease (n=7), encephalitis (n=6), ADEM (n=3), optic neuritis (ON, n=1), NMO (n=1), meningitis (n=1)] and MOG−NEG (n=45) demyelination.
Results:
CSF cytokine/chemokine levels were higher in both MOG−POS and MOG−NEG demyelination groups compared to controls. CSF in MOG−POS patients showed predominant elevation of B cell related cytokines/chemokines (CXCL13, APRIL, BAFF and CCL19) as well as some of Th17 related cytokines (IL-6 and G-CSF) compared to MOG−NEG group (all p< 0.01). In addition, some patients showed a correlation between MOG-Ab level and B cell related cytokines level.