Static and Dynamic Functional Gradient in Temporal Lobe Epilepsy and Juvenile Myoclonic Epilepsy
Abstract number :
2.317
Submission category :
5. Neuro Imaging / 5B. Functional Imaging
Year :
2024
Submission ID :
724
Source :
www.aesnet.org
Presentation date :
12/8/2024 12:00:00 AM
Published date :
Authors :
Presenting Author: Kangrun Wang, MD – First Affiliated Hospital of Wenzhou Medical University
Lili Long, MD – Xiangya Hospital Central South University
Rationale: Cognitive impairment is a common comorbidity of temporal lobe epilepsy (TLE) and juvenile myoclonic epilepsy (JME). The gradient captures the continuous transitions in connectivity, representing an intrinsic hierarchical architecture of brain. Gradient techniques provide a framework that could promote the understanding of static and dynamic neural correlations of cognitive decline.
Methods: We investigated 30 patients with TLE and hippocampal sclerosis, 34 patients with JME, and 29 healthy controls (HC) with verbal fluency task-based functional MRI and gradient techniques. The loading scores, task-based gradients, and dynamic features calculated with sliding window approaches were compared between HC, TLE, and JME.
Results: The gradient of SMC, dorsal attention network and salience network shifted to the transmodal end, and DMN was compressed in both TLE and JME. TLE had atypical activation-gradient relationships in somatomotor cortex (SMC), (para)limbic system (LIM) and default mode network (DMN). Activation/deactivation patterns in patients were more compiled to healthy gradient than the gradient of patients. The allegiance in real data was more widespread compared to static null models. Patients with TLE have lower dynamic recruitment of gradient compared to HC. The atypical activation pattern and impaired recruitment were correlated with verbal fluency scores, Digit Symbol Substitution Test scores, and Digit Span Test scores.
Conclusions: The static gradient alteration in TLE and JME were similar while the reorganization of activation pattern and dynamic gradient was profounder in TLE than in JME. The reorganization of activation patterns was not driven by the reconfiguration of static principal gradient. The principal gradient is dynamic during a task. Our results suggested that the principal gradient reconfiguration was caused by common neurodevelopmental abnormalities in TLE and JME, while activation patterns and dynamic gradients represented syndrome-specific functional reorganization that contributed to cognitive decline.
Funding: This study was supported by The National Natural Science Foundation of China (82171454), The Key Research and Development Program of Hunan Province (2022SK2042), and the Natural Science Foundation of Hunan Province Project (2022JJ30978).
Neuro Imaging