Abstracts

Rationale: Intra-Cerebral hemorrhage (ICH) is associated with high morbidity and mortality. Status Epilepticus (SE) is an uncommon condition that can develop in those with ICH. We designed this study to look at the epidemiology and outcomes of SE in those admitted with ICH.Methods: Using data from Nationwide Inpatient Sample database for years 2000-2010, hospitalizations of those aged ≥20 years with primary discharge diagnosis of ICH were identified using ICD-9-CM codes. Those with SE were also identified using ICD-9-CM codes. Only those who survived beyond first day of admission were included. Unadjusted incidence of SE among ICH hospitalizations over years was estimated and linear regression was used to assess trends over time. Multivariable logistic regression adjusted for patient and hospital characteristics was used to assess independent effect of SE on mortality.Results: Of estimated 626,883 (95% CI: 597,331-656,435) ICH hospitalizations, 0.3% (1,747) developed SE. Those with SE were younger (mean age 63.6±16.6 vs 69.2±15.2 years; p<0.001) and more often African-Americans (29.9% vs 16.2%; p<0.001). The unadjusted incidence of SE among those hospitalized with ICH increased over study period from 0.1% in 2000 to 0.4% in 2010 (p for trend=0.04). Unadjusted mortality was significantly higher in those with SE (27.9% vs 18.7%; p<0.001). SE was an independent predictor of mortality in those hospitalized with ICH (OR 1.76; 95% CI: 1.24-2.49) when adjusted for patient and hospital characteristics, primary payer and type, source and year of admission.Conclusions: Incidence of SE among those hospitalized with ICH is increasing. SE is associated with increased mortality in those admitted with ICH and is an independent predictor of mortality. Further studies are needed to understand the causes of rising incidence and higher mortality associated with SE in ICH hospitalizations.