Sulcal Variability in Children with Complex Partial Seizure Disorder
Abstract number :
1.167
Submission category :
Human Imaging-Pediatrics
Year :
2006
Submission ID :
6301
Source :
www.aesnet.org
Presentation date :
12/1/2006 12:00:00 AM
Published date :
Nov 30, 2006, 06:00 AM
Authors :
1Janelle L. Taylor, 2Rochelle Caplan, 2Jennifer G. Levitt, 1John Kim, and 1Arthur W. Toga
Recent studies demonstrate that children with cryptogenic complex partial seizures (CPS) have subtle neocortical and subcortical volumetric abnormalities (Daley et al., 2006a and b). Variable cognitive, linguistic, behavioral, and social deficits in these children (Caplan et al., 2004, 2005a and b, 2006) suggest widespread rather than focal involvement of brain structure and function. To begin to delineate the hypothesized widespread subtle structural abnormalities underlying these dysfunctions, this study compared the variability of sulcal lines in children with CPS compared to age and gender matched normal children., 27 (14 girls, 13 boys; mean age= 9.65 SD=2.31) children with CPS and 24 normal children (15 girls, 9 boys; mean age= 10.51 SD=1.72) completed T1-weighted MRI scans using a 1.5 Tesla GE scanner. Each scan was processed using a series of steps prior to sulcal delineation (Thompson et al., 1997, Shattuck et al. 2002). Two raters delineated 24 major cortical sulci on 3-dimensional hemispheric, high-resolution cerebral models, according to Thompson et al, (1997). Seven additional midline curves for each hemisphere were contoured to aid in anchoring midline anatomy across subjects. Regional averaging of sulci were generated using a novel parametric surface-based approach described in Thompson et al. (1996, 1997), and sulcal variabilities within each group were calculated., Normals showed increased variability ([gt]12mm) in the left perisylvian region including the secondary sulcus, while CPS subjects only showed increased variability ([gt]12mm) in the posterior branch of the superior temporal sulcus. Although both groups showed increased variability ([gt]12mm) in the right perisylvian region including the secondary sulcus, CPS subjects alone showed increased variability in the right inferior frontal sulcus ([gt]12mm). CPS subjects showed increased variability in the left posterior region of the anterior cingulate ([gt]10mm) while normal controls did not. In the right hemisphere normal controls, not CPS subjects, showed widespread variability ([gt]9mm) medially.[figure1], These preliminary findings suggest different patterns of sulcal variability adjacent to brain regions involved in language (left perisylvian, posterior superior temporal sulcus), emotional regulation, attention, conflict resolution (posterior region of the anterior cingulate), and self-monitoring (right inferior frontal sulcus) in CPS compared to normal children., (Supported by Funding supported by: NS32070 and MH067187.)
Neuroimaging