Abstracts

Rationale: . Febrile seizure (FS) is the most common convulsive event in children. Especially, complex FS has been recognized as one of the predictors for subsequent unprovoked seizure after FS. However, there has been few reports about whether if the three features of complex FS can affect the semiology of subsequent unprovoked seizure after FS. We performed this study to evaluate the correlation between the clinical characteristics of FS and subsequent unprovoked seizure, based on the three features of complex FS on Jeju Island, South Korea. Methods: We performed a retrospective study of patients with FS whose first FS developed between March 2007 and May 2015 and who were followed at the Pediatric Department at the Jeju National University Hospital. The variables included age, sex, type of seizure, duration, recurrence within 24 hours, onset age of first FS, family history of FS and epilepsy, electroencephalographic (EEG) findings, FS at < 39?, FS within 24h after fever and developmental delay. Results: 458 patients were found to have previous FS. Among them, subsequent unprovoked seizures occurred in 92 patients. The average age was 96.1 51.2 months. The mean age at the first unprovoked seizure attack was 62.3 42.1 months. Complex features in the first FS were noted in 34.7%. A family history of FS or epilepsy was found in 12.3% and 31.2% of patients, respectively. Developmental delay was shown in 27.2%. In 65 children, more than one unprovoked seizure occurred, which led to a diagnosis of epilepsy. Those were as follows : generalized tonic-clonic seizure alone (30 patients), absence epilepsy (10), benign rolandic epilepsy (5), frontal lobe epilepsy (8), occipital lobe epilepsy (4), temporal lobe epilepsy (3), panayiotopoulos syndrome (2) and unclassified (30). 29.3% (27/92) developed recurrent unprovoked seizure within 24 h. Prolonged unprovoked seizure (>